Salcaprozate sodium
Salcaprozate Sodium
CAS: 203787-91-1
Molecular Formula: C15H20NNaO4
Salcaprozate sodium - Names and Identifiers
Salcaprozate sodium - Physico-chemical Properties
| Molecular Formula | C15H20NNaO4 |
| Molar Mass | 301.31 |
| Storage Condition | Room Temprature |
| Physical and Chemical Properties | Bioactive Salcaprozate sodium (SNAC) is an oral absorption promoter with potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium can increase the lipophilicity caused by non-covalent macromolecular complexation, thereby increasing the passive transcellular penetration of small intestinal epithelial cells. |
| Use | Introduction 8-(2-hydroxybenzamido) sodium octanoate, SNAC for short, is a two-carbon phosphate compound absorption enhancer, used in the treatment of gastrointestinal diseases, it is especially suitable for gastrointestinal diseases caused by malabsorption of two carbon phosphate compounds. |
Salcaprozate sodium - Uses and synthesis methods
in vitro study
SNAC (12.5-400 μg/mL; 24 h) has no toxicity to Caco-2 cells, and the survival percentage is above 90% when SNAC is 200 μg/mL.
SNAC (50 and 200 μg/mL) improves the apparent permeability coeffcient (Papp) of RA and SA-B by 2.14-fold and 3.68-fold compared with the Papp of SAs solution.
in vivo studies
SNAC improves the oral absorption of both R1 and SAs and enhances bioavailability in rats.
SNAC (2000 mg/kg/d; oral gavage for 13 weeks) related mortality is evident only at the 2000-mg/kg/d level, 20% among males and 50% among females; no clear cause of death is evident.
SNAC (100-1000 mg/kg/d; oral gavage for 13 weeks) induces no mortality in the Wistar rat study at doses up to 1000 mg/kg/d.
Animal Model: Sprague-Dawley rats (6-7 weeks)
Dosage: 2000 mg/kg/d
Administration: Oral gavage for 13 weeks
Result: Induced 20% and 50% mortality in males and females at the dose of 2000 mg/kg/d.
Last Update：2024-04-09 21:01:54
Salcaprozate sodium - Nature
| storage conditions | Inert atmosphere,Room Temperature |
Last Update：2024-04-09 01:59:49
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